We describe the synthesis of 11C-labeled a-aminoisobutyric acid 2 from iodo[11C]methane and methyl N-(diphenylmethylen)-D,L-alaniate (5). The tetrabutylammonium fluoride (TBAF)-promoted a-[11C]methylation of sterically hindered analog 5 was a key step in our synthesis process. Total radiochemical conversion of 2 was high and a remote-controlled synthesis was carried out. A comparative tumor positron emission tomography (PET) imaging study using the same model mouse showed higher uptake of 2 than with 11C-labeled methionine and [18F] fluorodeoxyglucose (FDG)
International audienceThe use of radiolabeled non-natural amino acids can provide high contrast SPEC...
L-methionine (11C-MET), can potentially serve as an amino acid PET tracer for tumor imaging. The aim...
The aim of the study was to develop a simple 18F-labeledamino acid as a PET tracer for cerebral and ...
Among the β⁺ emitting isotopes, produced in medical cyclotrons, carbon-11 is promising radionuclide ...
Positron emission tomography (PET) is a nuclear medicine modality which provides quantitative images...
The positron-emitting radionuclide carbon-11 ((11)C, t1/2 = 20.3 min) possesses the unique potential...
Objectives: 18F-fluoro-deoxy-D-glucose (FDG) highly accumulates in tumors and is widely used for can...
For PET applications in oncological and neurological diagnostics, amino acids have been studied both...
Aiming at developing mechanism-based amino acid (18)F-PET tracers for tumor imaging, we synthesized ...
A no-carrier added synthesis of [11C]thymidine from cyclotron produced [11C]methyl iodide is present...
International audience11 C-Methylation (t1/2 = 20.4 min) is a main labeling strategy in the developm...
Radiolabeled tyrosine analogs enter cancer cells via upregulated amino acid transporter system and h...
N-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylat...
International audienceThe use of radiolabeled non-natural amino acids can provide high contrast SPEC...
L-methionine (11C-MET), can potentially serve as an amino acid PET tracer for tumor imaging. The aim...
The aim of the study was to develop a simple 18F-labeledamino acid as a PET tracer for cerebral and ...
Among the β⁺ emitting isotopes, produced in medical cyclotrons, carbon-11 is promising radionuclide ...
Positron emission tomography (PET) is a nuclear medicine modality which provides quantitative images...
The positron-emitting radionuclide carbon-11 ((11)C, t1/2 = 20.3 min) possesses the unique potential...
Objectives: 18F-fluoro-deoxy-D-glucose (FDG) highly accumulates in tumors and is widely used for can...
For PET applications in oncological and neurological diagnostics, amino acids have been studied both...
Aiming at developing mechanism-based amino acid (18)F-PET tracers for tumor imaging, we synthesized ...
A no-carrier added synthesis of [11C]thymidine from cyclotron produced [11C]methyl iodide is present...
International audience11 C-Methylation (t1/2 = 20.4 min) is a main labeling strategy in the developm...
Radiolabeled tyrosine analogs enter cancer cells via upregulated amino acid transporter system and h...
N-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylat...
International audienceThe use of radiolabeled non-natural amino acids can provide high contrast SPEC...
L-methionine (11C-MET), can potentially serve as an amino acid PET tracer for tumor imaging. The aim...
The aim of the study was to develop a simple 18F-labeledamino acid as a PET tracer for cerebral and ...