CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver

  • Kenna, Tony
  • O'Brien, Margaret
  • Hogan, Andrew
  • Exley, Mark A.
  • Porcelli, Steven A.
  • Hegarty, John E.
  • O'Farrelly, Cliona
  • Doherty, Derek G.
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Publication date
January 2007
Publisher
Springer Science and Business Media LLC

Abstract

CD1d-restricted natural killer T (NKT) cells expressing invariant Vα14Jα18 T cell receptor α-chains are abundant in murine liver and are implicated in the control of malignancy, infection and autoimmunity. Invariant NKT cells have potent anti-metastatic effects in mice and phase I clinical trials involving their homologues in humans are ongoing. However, invariant NKT cells are less abundant in human liver (∼0.5% of hepatic T cells) than in murine liver (up to 50%) and it is not known if other hepatic T cells are CD1-restricted. We have examined expression of CD1a, CD1b, CD1c and CD1d mRNA and protein in human liver and evaluated the reactivity of mononuclear cells (MNC) from histologically normal and tumour-bearing human liver specimens ag...

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