Data from: A quantitative electrophysiological biomarker of duplication 15q11.2-q13.1 syndrome

  • Frohlich, Joel
  • Senturk, Damla
  • Saravanapandian, Vidya
  • Golshani, Peyman
  • Reiter, Lawrence T.
  • Sankar, Raman
  • Thibert, Ronald
  • Distefano, Charlotte
  • Huberty, Scott
  • Cook, Edwin H.
  • Jeste, Shafali S.
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Publication date
March 2017

Abstract

Background: Duplications of 15q11.2-q13.1 (Dup15q syndrome) are highly penetrant for autism spectrum disorder (ASD). A distinct electrophysiological (EEG) pattern characterized by excessive activity in the beta band has been noted in clinical reports. We asked whether EEG power in the beta band, as well as in other frequency bands, distinguished children with Dup15q syndrome from those with non-syndromic ASD and then examined the clinical correlates of this electrophysiological biomarker in Dup15q syndrome. Methods: In the first study, we recorded spontaneous EEG from children with Dup15q syndrome (n = 11), age-and-IQ-matched children with ASD (n = 10) and age-matched typically developing (TD) children (n = 9) and computed rela...

Extracted data

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