This thesis aims to examine the behaviour of residential real estate prices and identify their determinants across Czech regions. After cointegration of the data was detected, a panel dynamic OLS estimator was employed. Initially, the effect of a wide range of variables on apartment prices is analyzed on quarterly data for all regions of the Czech Republic. Furthermore, an error correction model is employed to verify the existence of long-term equilibrium of apartment prices and the speed of price adjustment in the short run. The regression revealed that apartment prices are driven mainly by building plot prices, wages, unemployment, net migration and REER. Next, several regions with unique characteristics were excluded from the sample and ...