Electrochemical noise and impedance of Au electrode/electrolyte interfaces enabling extracellular detection of glioma cell populations

  • Schlett, Paul
  • Kintzel, Ulrike
  • Mailaender, Volker
  • Vandamme, Lode K. J.
  • Zeck, Gunther
  • Gomes, Henrique L.
  • Biscarini, Fabio
  • de Leeuw, Dago M.
Publication date
October 2016
Publisher
Springer Science and Business Media LLC
Journal
Scientific Reports

Abstract

Microelectrode arrays (MEA) record extracellular local field potentials of cells adhered to the electrodes. A disadvantage is the limited signal-to-noise ratio. The state-of-the-art background noise level is about 10 mu Vpp. Furthermore, in MEAs low frequency events are filtered out. Here, we quantitatively analyze Au electrode/electrolyte interfaces with impedance spectroscopy and noise measurements. The equivalent circuit is the charge transfer resistance in parallel with a constant phase element that describes the double layer capacitance, in series with a spreading resistance. This equivalent circuit leads to a Maxwell-Wagner relaxation frequency, the value of which is determined as a function of electrode area and molarity of an aqueou...

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