Here, we show that DNA-mediated charge transport (CT) can lead to the oxidation of thiols to form disulfide bonds in DNA. DNA assemblies were prepared possessing anthraquinone (AQ) as a photooxidant spatially separated on the duplex from two SH groups incorporated into the DNA backbone. Upon AQ irradiation, HPLC analysis reveals DNA ligated through a disulfide. The reaction efficiency is seen to vary in assemblies containing intervening DNA mismatches, confirming that the reaction is DNA-mediated. Interestingly, one intervening mismatch near the thiols promotes an increase in efficiency, which we attribute to increased base dynamics. Hence, here, where the reaction is on the backbone rather than within the base stack, stacking perturbations...
Photochemical reactions on DNA assemblies containing tethered photooxidants, particularly metalloint...
Sites of oxidative damage in mitochondrial DNA have been identified on the basis of DNA-mediated cha...
The reaction of calicheamicin γ_1 (1) with glutathione (GSH) has been studied in the presence of dou...
Here, we show that DNA-mediated charge transport (CT) can lead to the oxidation of thiols to form di...
The electrochemistry of disulfides incorporated into the sugar−phosphate backbone of pyrene-modified...
Many experiments have now shown that double helical DNA can serve as a conduit for efficient charge ...
A direct comparison of DNA charge transport (CT) with different photooxidants has been made. Photoox...
Transcription factor p53 plays a critical role in the cellular response to stress stimuli. We have s...
In this study, the influence of the terminal phosphorothioate (PT) internucleotide bond in ds-DNA on...
In all organisms, oxidation threatens the integrity of the genome. DNA-mediated charge transport (CT...
Background: The DNA double helix is composed of an array of aromatic heterocyclic base pairs and, as...
AbstractBackground: The DNA double helix is composed of an array of aromatic heterocyclic base pairs...
Charge transport (CT) through the DNA base pairs provides a means to promote redox reactions at a re...
The unique characteristics of DNA charge transport (CT) have prompted an examination of roles for th...
The DNA duplex is an exquisite macromolecular array that stores genetic information to encode protei...
Photochemical reactions on DNA assemblies containing tethered photooxidants, particularly metalloint...
Sites of oxidative damage in mitochondrial DNA have been identified on the basis of DNA-mediated cha...
The reaction of calicheamicin γ_1 (1) with glutathione (GSH) has been studied in the presence of dou...
Here, we show that DNA-mediated charge transport (CT) can lead to the oxidation of thiols to form di...
The electrochemistry of disulfides incorporated into the sugar−phosphate backbone of pyrene-modified...
Many experiments have now shown that double helical DNA can serve as a conduit for efficient charge ...
A direct comparison of DNA charge transport (CT) with different photooxidants has been made. Photoox...
Transcription factor p53 plays a critical role in the cellular response to stress stimuli. We have s...
In this study, the influence of the terminal phosphorothioate (PT) internucleotide bond in ds-DNA on...
In all organisms, oxidation threatens the integrity of the genome. DNA-mediated charge transport (CT...
Background: The DNA double helix is composed of an array of aromatic heterocyclic base pairs and, as...
AbstractBackground: The DNA double helix is composed of an array of aromatic heterocyclic base pairs...
Charge transport (CT) through the DNA base pairs provides a means to promote redox reactions at a re...
The unique characteristics of DNA charge transport (CT) have prompted an examination of roles for th...
The DNA duplex is an exquisite macromolecular array that stores genetic information to encode protei...
Photochemical reactions on DNA assemblies containing tethered photooxidants, particularly metalloint...
Sites of oxidative damage in mitochondrial DNA have been identified on the basis of DNA-mediated cha...
The reaction of calicheamicin γ_1 (1) with glutathione (GSH) has been studied in the presence of dou...