AbstractTranslationally controlled tumour protein (TCTP) is involved in malignant transformation and regulation of apoptosis. It has been postulated to serve as a guanine nucleotide exchange factor for the small G-protein Rheb. Rheb functions in the PI3 kinase/mTOR pathway. The study presented here was initiated to characterise the interaction between TCTP and Rheb biochemically. Since (i) no exchange activity of TCTP towards Rheb could be detected in vitro, (ii) no interaction between TCTP and Rheb could be detected by NMR spectroscopy, and (iii) no effect of TCTP depletion in cells on the direct downstream targets of Rheb could be observed in vivo, this study shows that TCTP is unlikely to be a guanine nucleotide exchange factor for Rheb....
Signaling through mammalian target of rapamycin complex 1 (mTORC1) is stimulated by amino acids and ...
AbstractThe small G protein Rheb (Ras homologue enriched in brain) is known to promote mammalian tar...
The Rheb1 and Rheb2 small GTPases and their effector mTOR are aberrantly activated in human cancer a...
AbstractTranslationally controlled tumour protein (TCTP) is involved in malignant transformation and...
The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, forti...
The activator of mammalian target of rapamycin complex 1 (mTORC1), Ras homolog enriched in brain (Rh...
Translationally controlled tumor protein (TCTP) is a highly conserved housekeeping protein present i...
Ras homolog enriched in brain (RHEB) is a member of the Ras superfamily of small GTPases that are re...
Translationally controlled tumor protein (TCTP) is a highly conserved housekeeping protein present i...
The translationally controlled tumor-associated proteins (TCTPs) are a highly conserved and abundant...
In this review we highlight recent progress in the study of Rheb family GTPases. Structural studies ...
SummaryBackground: The target of rapamycin (TOR), in complex with the proteins raptor and LST8 (TOR ...
The Rheb1 and Rheb2 small GTPases and their effector mTOR are aberrantly activated in human cancer a...
International audienceRecently, we demonstrated that the expression levels of the translationally co...
EditorialInternational audienceTranslationally-controlled tumor-associated protein (TCTP) has been d...
Signaling through mammalian target of rapamycin complex 1 (mTORC1) is stimulated by amino acids and ...
AbstractThe small G protein Rheb (Ras homologue enriched in brain) is known to promote mammalian tar...
The Rheb1 and Rheb2 small GTPases and their effector mTOR are aberrantly activated in human cancer a...
AbstractTranslationally controlled tumour protein (TCTP) is involved in malignant transformation and...
The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, forti...
The activator of mammalian target of rapamycin complex 1 (mTORC1), Ras homolog enriched in brain (Rh...
Translationally controlled tumor protein (TCTP) is a highly conserved housekeeping protein present i...
Ras homolog enriched in brain (RHEB) is a member of the Ras superfamily of small GTPases that are re...
Translationally controlled tumor protein (TCTP) is a highly conserved housekeeping protein present i...
The translationally controlled tumor-associated proteins (TCTPs) are a highly conserved and abundant...
In this review we highlight recent progress in the study of Rheb family GTPases. Structural studies ...
SummaryBackground: The target of rapamycin (TOR), in complex with the proteins raptor and LST8 (TOR ...
The Rheb1 and Rheb2 small GTPases and their effector mTOR are aberrantly activated in human cancer a...
International audienceRecently, we demonstrated that the expression levels of the translationally co...
EditorialInternational audienceTranslationally-controlled tumor-associated protein (TCTP) has been d...
Signaling through mammalian target of rapamycin complex 1 (mTORC1) is stimulated by amino acids and ...
AbstractThe small G protein Rheb (Ras homologue enriched in brain) is known to promote mammalian tar...
The Rheb1 and Rheb2 small GTPases and their effector mTOR are aberrantly activated in human cancer a...