The Fluctuating Natural Course of CCSVI in MS Patients and Controls, a Prospective Follow-Up

  • Van den Berg Petronella J.
  • Visser Leo H.
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Publication date
November 2013
Publisher
Public Library of Science

Abstract

A new treatable venous disorder, chronic cerebrospinal venous insufficiency (CCSVI), has been proposed in patients with multiple sclerosis. The natural course of CCSVI has not been examined yet. This is crucial given the fact that surgical procedures are increasingly offered to MS patients to treat venous stenosis.To document the natural course of venous haemodynamics we performed extra- and transcranial echo colour Doppler (ECD) in 52 multiple sclerosis patients and 28 healthy controls (HC) and re-examined this group after a median period of 16 weeks. The reexamination was done being blinded to the initial findings and the patients did not undergo any intervention.The ECD examination at baseline showed CCSVI in 5 (9.6%) of the 52 multiple ...

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