Visceral obesity holds a central position in the concept of the metabolic syndrome characterized by glucose intolerance in humans. However, until now it is unclear if obesity by itself is responsible for the development of glucose intolerance.We have used a novel polygenic mouse model characterized by genetically fixed obesity (DU6) and addressed age- and high fat diet-dependent glucose tolerance.Phenotype selection over 146 generations increased body weight by about 2.7-fold in male 12-week DU6 mice (P<0.0001) if compared to unselected controls (Fzt:DU). Absolute epididymal fat mass was particularly responsive to weight selection and increased by more than 5-fold (P<0.0001) in male DU6 mice. At an age of 6 weeks DU6 mice consumed about twi...
The FATZO/Pco mouse is the result of a cross of the C57BL/6J and AKR/J strains. The crossing of thes...
Although obesity rates are rapidly rising, caloric restriction re-mains one of the few safe therapie...
Obesity, a phenotype having high heritability in humans, constitutes the major risk factor predispos...
Aims/Hypothesis: Visceral obesity holds a central position in the concept of the metabolic syndrome ...
AIMS/HYPOTHESIS: Visceral obesity holds a central position in the concept of the metabolic syndrome ...
Yellow KK mice carrying the \u27yellow obese\u27 gene Ay are a well established polygenic model for ...
Metabolic disorders, like diabetes and obesity, are pathogenic outcomes of imbalance in glucose meta...
<div><p>Metabolic disorders, like diabetes and obesity, are pathogenic outcomes of imbalance in gluc...
Obesity in many current pre-clinical animal models of obesity and diabetes is mediated by monogenic ...
Background: The C57BL/6 mouse fed a high fat diet is a common and valuable model in experimental stu...
High phenotypic variation in diet-induced obesity in male C57BL/6J inbred mice suggests a molecular ...
This study characterizes the high-fat diet-fed mouse as a model for impaired glucose tolerance (IGT)...
High-fat (HF) diet-induced obesity and insulin insensitivity are associated with inflammation, parti...
Decreased metabolic flexibility, i.e. a compromised ability to adjust fuel oxidation to fuel availab...
Obesity is characterized by a dysregulated immune system, which may causally associate with insulin ...
The FATZO/Pco mouse is the result of a cross of the C57BL/6J and AKR/J strains. The crossing of thes...
Although obesity rates are rapidly rising, caloric restriction re-mains one of the few safe therapie...
Obesity, a phenotype having high heritability in humans, constitutes the major risk factor predispos...
Aims/Hypothesis: Visceral obesity holds a central position in the concept of the metabolic syndrome ...
AIMS/HYPOTHESIS: Visceral obesity holds a central position in the concept of the metabolic syndrome ...
Yellow KK mice carrying the \u27yellow obese\u27 gene Ay are a well established polygenic model for ...
Metabolic disorders, like diabetes and obesity, are pathogenic outcomes of imbalance in glucose meta...
<div><p>Metabolic disorders, like diabetes and obesity, are pathogenic outcomes of imbalance in gluc...
Obesity in many current pre-clinical animal models of obesity and diabetes is mediated by monogenic ...
Background: The C57BL/6 mouse fed a high fat diet is a common and valuable model in experimental stu...
High phenotypic variation in diet-induced obesity in male C57BL/6J inbred mice suggests a molecular ...
This study characterizes the high-fat diet-fed mouse as a model for impaired glucose tolerance (IGT)...
High-fat (HF) diet-induced obesity and insulin insensitivity are associated with inflammation, parti...
Decreased metabolic flexibility, i.e. a compromised ability to adjust fuel oxidation to fuel availab...
Obesity is characterized by a dysregulated immune system, which may causally associate with insulin ...
The FATZO/Pco mouse is the result of a cross of the C57BL/6J and AKR/J strains. The crossing of thes...
Although obesity rates are rapidly rising, caloric restriction re-mains one of the few safe therapie...
Obesity, a phenotype having high heritability in humans, constitutes the major risk factor predispos...