Lifelong Obesity in a Polygenic Mouse Model Prevents Age- and Diet-Induced Glucose Intolerance– Obesity Is No Road to Late-Onset Diabetes in Mice

  • Renne Ulla
  • Langhammer Martina
  • Brenmoehl Julia
  • Walz Christina
  • Zeissler Anja
  • Tuchscherer Armin
  • Piechotta Marion
  • Wiesner Rudolf J.
  • Bielohuby Maximilian
  • Hoeflich Andreas
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Publication date
November 2013
Publisher
Public Library of Science

Abstract

Visceral obesity holds a central position in the concept of the metabolic syndrome characterized by glucose intolerance in humans. However, until now it is unclear if obesity by itself is responsible for the development of glucose intolerance.We have used a novel polygenic mouse model characterized by genetically fixed obesity (DU6) and addressed age- and high fat diet-dependent glucose tolerance.Phenotype selection over 146 generations increased body weight by about 2.7-fold in male 12-week DU6 mice (P<0.0001) if compared to unselected controls (Fzt:DU). Absolute epididymal fat mass was particularly responsive to weight selection and increased by more than 5-fold (P<0.0001) in male DU6 mice. At an age of 6 weeks DU6 mice consumed about twi...

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