spp. Induces Selective Growth Inhibition of PC-3 and MeWo Human Cancer Cells through Modulation of Cell Cycle and Induction of Apoptosis

  • Tang Yin-Quan
  • Jaganath Indu Bala
  • Sekaran Shamala Devi
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Publication date
September 2010
Publisher
Public Library of Science

Abstract

) against skin melanoma and prostate cancer cells. induced a Go/G1-phase arrest on PC-3 cells and a S-phase arrest on MeWo cells and these were accompanied by accumulation of cells in the Sub-G1 (apoptosis) phase. The cytotoxic properties may be due to the presence of polyphenol compounds such as ellagitannins, gallotannins, flavonoids and phenolic acids found both in the water and methanol extract of the plants. may be sourced for the development of a potent apoptosis-inducing anticancer agent

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