THE ROLE OF MITOCHONDRIAL CALCIUM OVERLOAD IN CYCLOSPORINE A-INDUCED GINGIVAL HYPERPLASIA

  • Ancuţa Goriuc
  • Bogdan Minea
  • Foia Liliana
  • Marcel Costuleanu
  • Raluca Jipu
  • Vasilica Toma
  • Vlad Cristiana
  • Ionuţ Luchian
  • Ioana Mârţu
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Publication date
October 2017
Publisher
Romanian Society of Oral Rehabilitation
Journal
2066-7000

Abstract

Aim of the study Apoptosis (programmed cell death) is a possible mechanism of cyclosporine A (CsA)-induced gingival hyperplasia. The purpose of this paper is to study the effect of ionomycin and ionophore A23187 on normal gingival fibroblasts and also on fibroblasts treated with CsA using flow cytometry methods. Material and methods All of our experiments were performed on fibroblasts obtained from gingival male rats through explant technique and the opening of the mitochondrial transient permeability pore as a result of calcium cytosol overload was followed using calcein AM and CoCl2. Results Our results show a significant difference between normal gingival fibroblasts and those treated with CsA when using ionophore A23187. On the other ha...

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