Systemic insecticide treatment of the canine reservoir of Trypanosoma cruzi induces high levels of lethality in Triatoma infestans, a principal vector of Chagas disease

  • Ariel Loza
  • Adrianna Talaga
  • Gladys Herbas
  • Ruben Jair Canaviri
  • Thalia Cahuasiri
  • Laura Luck
  • Alvaro Guibarra
  • Raquel Goncalves
  • Juan Antonio Pereira
  • Sonia A. Gomez
  • Albert Picado
  • Louisa Alexandra Messenger
  • Caryn Bern
  • Orin Courtenay
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Publication date
July 2017
Publisher
Springer Science and Business Media LLC
Journal
Parasites & Vectors

Abstract

Abstract Background Despite large-scale reductions in Chagas disease prevalence across Central and South America, Trypanosoma cruzi infection remains a considerable public health problem in the Gran Chaco region where vector-borne transmission persists. In these communities, peridomestic animals are major blood-meal sources for triatomines, and household presence of infected dogs increases T. cruzi transmission risk for humans. To address the pressing need for field-friendly, complementary methods to reduce triatomine infestation and interrupt T. cruzi transmission, this study evaluated the systemic activity of three commercial, oral, single dose insecticides Fluralaner (Bravecto®), Afoxolaner (NexGard®) and Spinosad (Comfortis®) in canine ...

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