Genotyping Analyses of Tuberculosis Cases in U.S.- and Foreign-Born Massachusetts Residents

  • Sharon Sharnprapai
  • Ann C. Miller
  • Robert Suruki
  • Edward Corkren
  • Sue Etkind
  • Jeffrey Driscoll
  • Michael McGarry
  • Edward Nardell
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Publication date
November 2002
Publisher
Centers for Disease Control and Prevention (CDC)
Journal
Emerging Infectious Diseases

Abstract

We used molecular genotyping to further understand the epidemiology and transmission patterns of tuberculosis (TB) in Massachusetts. The study population included 983 TB patients whose cases were verified by the Massachusetts Department of Public Health between July 1, 1996, and December 31, 2000, and for whom genotyping results and information on country of origin were available. Two hundred seventy-two (28%) of TB patients were in genetic clusters, and isolates from U.S-born were twice as likely to cluster as those of foreign-born (odds ratio [OR] 2.29, 95% confidence interval [CI] 1.69, 3.12). Our results suggest that restriction fragment length polymorphism analysis has limited capacity to differentiate TB strains when the isolate conta...

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