A Survey of Autoantibodies to Self Antigens in Graves' Disease Patients with Thyroid-Associated Ophthalmopathy

  • R. Bei
  • M. Romano
  • M.P. Caputo
  • G. Sconocchia
  • B. Capuani
  • A. Coppola
  • C. Nucci
  • D. Pastore
  • A. Bellia
  • R. Mancino
  • K. Andreadi
  • M. Cerilli
  • A. Bertoli
  • A. Modesti
  • D. Lauro
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Publication date
May 2013
Publisher
SAGE Publications
Journal
European Journal of Inflammation

Abstract

Thyroid Associated Ophthalmopathy (TAO) is a complex pathology to treat and a considerable threat for Graves' Disease (GD) patients. Thus, there is great interest to find tools able to predict the onset and prognosis of TAO. Chronic inflamed tissues are characterized by tissue damage and recruitment of cells from the bloodstream, events that can lead to self-antigen exposure and induce autoimmune phenomena. In this study, we determined whether the occurrence of antibody anti-extracellular matrix (ECM) molecules [Collagen CI, CIII, CIV, CV, laminin (LM) and fibronectin, (FN)], anti-smooth muscle (ASM), anti-nuclear antigen (ANA), anti-ribonucleoprotein (RNP) and anti-thyroid-stimulating hormone (TSH) receptor (TRAbs) were associated with TAO...

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