Latent/quiescent HSV-1 genomes co-localize with the HIRA complex.

  • Camille Cohen (2440810)
  • Armelle Corpet (3114204)
  • Simon Roubille (5775452)
  • Mohamed Ali Maroui (136132)
  • Nolwenn Poccardi (3114207)
  • Antoine Rousseau (144372)
  • Constance Kleijwegt (5775455)
  • Olivier Binda (1483945)
  • Pascale Texier (3114210)
  • Nancy Sawtell (144374)
  • Marc Labetoulle (144375)
  • Patrick Lomonte (133734)
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Publication date
October 2018
Publisher
Public Library of Science (PLoS)

Abstract

(A) Immuno-FISH performed in human primary fibroblasts (BJ cells) infected for 2 days with the replication-defective HSV-1 virus in1374. HIRA (i), UBN1 (ii), CABIN1 (iii), ASF1a (iv) (green), and HSV-1 genomes (red) were detected. Scale bars = 5 μm. (B) Immuno-FISH performed in adult mouse primary TG neuron cultures infected for 2 days with in1374. Mouse Hira (mHira, green), HSV-1 genomes (red), and nucleus (inset, gray) are detected. Scale bar = 5 μm. (C) Same as (B) but in TG neurons from 6-day HSV-1wt-infected mice. Scale bars = 10 μm. (D) Same as (B) in TG neurons of 28-day HSV-1wt-infected mice. Scale bars = 10 μm. (E) Quantifications of immuno-FISH performed in BJ cells infected with in1374 at early times pi. Data represent the percen...

Extracted data

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