α-Synuclein (α-syn) is found to be naturally present in biofluids such as cerebrospinal fluid (CSF) and serum. Human serum albumin (HSA) is the most abundant protein found in these biofluids, which, beyond transporting hormones and drugs, also exerts a chaperone-like activity binding other proteins in blood and inhibiting their aggregation. Contrasting results are reported in the literature about the effects of albumin on α-syn aggregation. We characterized the binding region of HSA on α-syn by high-field solution NMR spectroscopy and the effect of HSA on α-syn aggregation by thioflavin-T (ThT) fluorescence under both low-ionic-strength and physiological conditions at the albumin concentration in serum and CSF. We found that HSA, at the con...
<div><p>The misfolding and aggregation of proteins is involved in some of the most prevalent neurode...
In this paper, binding interaction of Coumarin, including 4-Methylesculetin, Esculetin and Esculin, ...
Protein aggregation is a ubiquitous phenomenon underpinning the origins of a range of human diseases...
Human serum albumin is a highly water soluble globular monomeric plasma protein with a relative mole...
Regulation of amyloid-?? (A??) aggregation by metal ions and proteins is essential for understanding...
Regulation of amyloid-β (Aβ) aggregation by metal ions and proteins is essential for understanding t...
The importance of protein–nanoparticle (NP) conjugates for biomedical applications has seen an expon...
AbstractA promising strategy to control the aggregation of the Alzheimer's Aβ peptide in the brain i...
The present study focuses on the determination of the biologically significant N-acetylneuraminic ac...
The present study focuses on the determination of the biologically significant N-acetylneuraminic ac...
Thioflavin T is a fluorescent probe used to monitor formation of cross [beta]-sheet rich amyloid fib...
The behaviour and function of biomolecules represent a fundamental aspect in modulating the activity...
This thesis focuses on the study of molecular interactions of metabolites in biofluids by Nuclear Ma...
Alpha-synuclein (αSynuclein) accumulation and aggregation is related to many neurodegenerative disea...
Increasing evidence links the misfolding and aberrant self-assembly of proteins with the molecular e...
<div><p>The misfolding and aggregation of proteins is involved in some of the most prevalent neurode...
In this paper, binding interaction of Coumarin, including 4-Methylesculetin, Esculetin and Esculin, ...
Protein aggregation is a ubiquitous phenomenon underpinning the origins of a range of human diseases...
Human serum albumin is a highly water soluble globular monomeric plasma protein with a relative mole...
Regulation of amyloid-?? (A??) aggregation by metal ions and proteins is essential for understanding...
Regulation of amyloid-β (Aβ) aggregation by metal ions and proteins is essential for understanding t...
The importance of protein–nanoparticle (NP) conjugates for biomedical applications has seen an expon...
AbstractA promising strategy to control the aggregation of the Alzheimer's Aβ peptide in the brain i...
The present study focuses on the determination of the biologically significant N-acetylneuraminic ac...
The present study focuses on the determination of the biologically significant N-acetylneuraminic ac...
Thioflavin T is a fluorescent probe used to monitor formation of cross [beta]-sheet rich amyloid fib...
The behaviour and function of biomolecules represent a fundamental aspect in modulating the activity...
This thesis focuses on the study of molecular interactions of metabolites in biofluids by Nuclear Ma...
Alpha-synuclein (αSynuclein) accumulation and aggregation is related to many neurodegenerative disea...
Increasing evidence links the misfolding and aberrant self-assembly of proteins with the molecular e...
<div><p>The misfolding and aggregation of proteins is involved in some of the most prevalent neurode...
In this paper, binding interaction of Coumarin, including 4-Methylesculetin, Esculetin and Esculin, ...
Protein aggregation is a ubiquitous phenomenon underpinning the origins of a range of human diseases...