53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of S3BP1 in DNA-damage checkpoint activation and DNA repair, and the mechanisms of its recruitment and activation following DNA damage. We focus in particular on the role of covalent histone modifications in this process
The tumour suppressor p53 binding protein 1 (53BP1), a fundamental node in DNA double strand break (...
The mechanisms that localise 53BP1 to sites of DNA double-strand breaks (DSBs) have remained elusive...
SummaryThe DNA damage response (DDR) protein 53BP1 protects DNA ends from excessive resection in G1,...
53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-damage response, and is...
53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-damage response, and is...
Upon DNA damage, p53-binding protein 1 (53BP1) relocalizes to sites of DNA double-strand breaks and ...
DNA damage may result in various pathological conditions and contributes to aging and development of...
DNA double-strand break (DSB) signalling and repair is crucial to preserve genomic integrity and mai...
The protein p53 binding protein one (53BP1) was discovered in a yeast two-hybrid screen that used th...
53BP1, a protein proposed to function as a transcriptional coactivator of the p53 tumor suppressor, ...
Double-strand breaks (DSBs) are toxic lesions that can be generated by exposure to genotoxic agents ...
Cancer is the major cause of death for people in middle age. It results from cell transformation in...
53BP1 is a conserved nuclear protein that localizes rapidly at the sites of double strand breaks fol...
p53-binding protein 1 (53BP1) is a conserved nuclear protein that is rapidly recruited to sites of D...
Abstract To maintain genomic stability and ensure the fidelity of chromosomal transmission, cells re...
The tumour suppressor p53 binding protein 1 (53BP1), a fundamental node in DNA double strand break (...
The mechanisms that localise 53BP1 to sites of DNA double-strand breaks (DSBs) have remained elusive...
SummaryThe DNA damage response (DDR) protein 53BP1 protects DNA ends from excessive resection in G1,...
53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-damage response, and is...
53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-damage response, and is...
Upon DNA damage, p53-binding protein 1 (53BP1) relocalizes to sites of DNA double-strand breaks and ...
DNA damage may result in various pathological conditions and contributes to aging and development of...
DNA double-strand break (DSB) signalling and repair is crucial to preserve genomic integrity and mai...
The protein p53 binding protein one (53BP1) was discovered in a yeast two-hybrid screen that used th...
53BP1, a protein proposed to function as a transcriptional coactivator of the p53 tumor suppressor, ...
Double-strand breaks (DSBs) are toxic lesions that can be generated by exposure to genotoxic agents ...
Cancer is the major cause of death for people in middle age. It results from cell transformation in...
53BP1 is a conserved nuclear protein that localizes rapidly at the sites of double strand breaks fol...
p53-binding protein 1 (53BP1) is a conserved nuclear protein that is rapidly recruited to sites of D...
Abstract To maintain genomic stability and ensure the fidelity of chromosomal transmission, cells re...
The tumour suppressor p53 binding protein 1 (53BP1), a fundamental node in DNA double strand break (...
The mechanisms that localise 53BP1 to sites of DNA double-strand breaks (DSBs) have remained elusive...
SummaryThe DNA damage response (DDR) protein 53BP1 protects DNA ends from excessive resection in G1,...