CDP-choline accumulation in breast and colorectal cancer cells treated with a GSK-3-targeting inhibitor

17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2

Brandes, Alissa H
Ward, Christopher S
Ronen, Sabrina M

October 2010

Abstract Introduction 17-allyamino-17-demethoxygeldanamycin (17-AAG), a small molecule inhibitor of ...

Activation of phosphatidylcholinespecific phospholipase C in breast and ovarian cancer: Impact on mrs-detected choline metabolic profile and perspectives for targeted therapy

F. Podo
L. Paris
S. Cecchetti
F. Spadaro
L. Abalsamo
C. Ramoni
A. Ricci
M.E. Pisanu
F. Sardanelli
R. Canese
E. Iorio

August 2016

Elucidation of molecular mechanisms underlying the aberrant phosphatidylcholine cycle in cancer cell...

The Effect of Antitumor Glycosides on Glioma Cells and Tissues as Studied by Proton HR-MAS NMR Spectroscopy

García-Álvarez, Isabel
Garrido, Leoncio
Romero-Ramírez, Lorenzo
Nieto-Sampedro, Manuel
Fernández-Mayoralas, Alfonso
Campos-Olivas, Ramón

December 2014

The effect of the treatment with glycolipid derivatives on the metabolic profile of intact glioma ce...

Probing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy : routes to glycogen synthase kinase 3

Phyu, Su M
Tseng, Chih-Chung Tseng
Fleming, Ian N
Smith, Tim A D

November 2016

Professor Matteo Zanda and Professor Marcel Jaspars are gratefully acknowledged for the use of the N...

A novel small molecule antagonist of choline kinase-alpha that simultaneously suppresses MAPK and PI3K/AKT signaling

Clem, Brian F.
Clem, Amy L.
Goswami, Umesh
Arumugam, Sengodagounder
Telang, Sucheta
Trent, John O.
Chesney, Jason A.

July 2011

Choline kinase-alpha expression and activity are increased in multiple human neoplasms as a result o...

Is going for cure in CML targeting aberrant Glycogen Synthase Kinase 3β?

SAPONARO, CONCETTA
MAFFIA, Michele
COLUCCIA, ADDOLORATA
Di Renzo, Nicola

January 2016

Chronic Myelogenous Leukemia (CML)-initiating cells (CICs) express the hybrid oncoprotein BCR-ABL at...

Targeting GSK3 and Associated Signaling Pathways Involved in Cancer

June 2020

open14siFUNDING: JAM: SLA, and LSS were supported in part by a grant from East Carolina University G...

The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth

Trousil, Sebastian
Kaliszczak, Maciej
Schug, Zachary
Nguyen, Quang-De
Tomasi, Giampaolo
Favicchio, Rosy
Brickute, Diana
Fortt, Robin
Twyman, Frazer J.
Carroll, Laurence
Kalusa, Andrew
Navaratnam, Naveenan
Adejumo, Thomas
Carling, David
Gottlieb, Eyal
Aboagye, Eric O.

May 2016

The glycerophospholipid phosphatidylcholine is the most abundant phospholipid species of eukaryotic ...

Therapeutic Potential of Modulating Glycogen Synthase Kinase 3 Activity in Tumor Cell-lines

Kumar, Megha

March 2021

Glycogen synthase kinase3 (GSK3) is a constitutively active serine/theronine kinasethat has two isof...

GSK-3 Inhibition: A Novel Approach to Sensitization of Chemo-resistant Pancreatic Cancer Cells

Mamaghani, Shadi

August 2011

The aggressive nature of pancreatic cancer, characterized by invasiveness, resistance to treatment, ...

Quantitative 31P HR-MAS MR spectroscopy for detection of response to PI3K/mTOR inhibition in breast cancer xenografts

Esmaeili, Morteza
Bathen, Tone Frost
Engebråten, Olav
Mælandsmo, Gunhild
Gribbestad, Ingrid S
Moestue, Siver Andreas

January 2014

PURPOSE: Phospholipid metabolites are of importance in cancer studies, and have been suggested as c...

Inhibition of GSK-3 induces differentiation and impaired glucose metabolism in renal cancer

Pal, K.
Cao, Y.
Gaisina, I.
Bhattacharya, S.
Dutta, S.
Wang, E.
Gunosewoyo, Hendra
Kozikowski, A.
Billadeau, D.
Mukhopadhyay, D.

January 2014

Glycogen synthase kinase-3 (GSK-3), a constitutively active serine/threonine kinase, is a key regula...

Metabolic changes in glioblastomas in response to choline kinase inhibition: In vivo MRS in rodent models

Bhaduri, Sourav
Kelly, Claire Louise
Lesbats, Clementine
Sharkey, Jack
Ressel, Lorenzo
Mukherjee, Soham
Platt, Mark David
Delikatny, Edward J
Poptani, Harish

January 2022

Changes in glioblastoma (GBM) metabolism was investigated in response to JAS239, a choline kinase in...

Inhibition of GSK-3β activity attenuates proliferation of human colon cancer cells in rodents

Shakoori Abbas
Mai Wei
Miyashita Katsuyoshi
Yasumoto Kazuo
Takahashi Yutaka
Ooi Akishi
Kawakami Kazuyuki
Minamoto Toshinari

September 2007

The authors\u27 recent discovery that glycogen synthase kinase-3β (GSK-3β) participates in colon can...

Combination treatment of cancer cells with pan-Akt and pan-mTOR inhibitors : effects on cell cycle distribution, p-Akt expression level and radiolabelled-choline incorporation

Phyu, Su Myat
Smith, Tim A. D.

June 2019

Open Access via Springer Compact Agreement Acknowledgements The University of Aberdeen Development T...

17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2

Brandes, Alissa H
Ward, Christopher S
Ronen, Sabrina M

October 2010

Abstract Introduction 17-allyamino-17-demethoxygeldanamycin (17-AAG), a small molecule inhibitor of ...

Activation of phosphatidylcholinespecific phospholipase C in breast and ovarian cancer: Impact on mrs-detected choline metabolic profile and perspectives for targeted therapy

F. Podo
L. Paris
S. Cecchetti
F. Spadaro
L. Abalsamo
C. Ramoni
A. Ricci
M.E. Pisanu
F. Sardanelli
R. Canese
E. Iorio

August 2016

Elucidation of molecular mechanisms underlying the aberrant phosphatidylcholine cycle in cancer cell...

The Effect of Antitumor Glycosides on Glioma Cells and Tissues as Studied by Proton HR-MAS NMR Spectroscopy

García-Álvarez, Isabel
Garrido, Leoncio
Romero-Ramírez, Lorenzo
Nieto-Sampedro, Manuel
Fernández-Mayoralas, Alfonso
Campos-Olivas, Ramón

December 2014

The effect of the treatment with glycolipid derivatives on the metabolic profile of intact glioma ce...

Probing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy : routes to glycogen synthase kinase 3

Phyu, Su M
Tseng, Chih-Chung Tseng
Fleming, Ian N
Smith, Tim A D

November 2016

Professor Matteo Zanda and Professor Marcel Jaspars are gratefully acknowledged for the use of the N...

A novel small molecule antagonist of choline kinase-alpha that simultaneously suppresses MAPK and PI3K/AKT signaling

Clem, Brian F.
Clem, Amy L.
Goswami, Umesh
Arumugam, Sengodagounder
Telang, Sucheta
Trent, John O.
Chesney, Jason A.

July 2011

Choline kinase-alpha expression and activity are increased in multiple human neoplasms as a result o...

Is going for cure in CML targeting aberrant Glycogen Synthase Kinase 3β?

SAPONARO, CONCETTA
MAFFIA, Michele
COLUCCIA, ADDOLORATA
Di Renzo, Nicola

January 2016

Chronic Myelogenous Leukemia (CML)-initiating cells (CICs) express the hybrid oncoprotein BCR-ABL at...

Targeting GSK3 and Associated Signaling Pathways Involved in Cancer

June 2020

open14siFUNDING: JAM: SLA, and LSS were supported in part by a grant from East Carolina University G...

The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth

Trousil, Sebastian
Kaliszczak, Maciej
Schug, Zachary
Nguyen, Quang-De
Tomasi, Giampaolo
Favicchio, Rosy
Brickute, Diana
Fortt, Robin
Twyman, Frazer J.
Carroll, Laurence
Kalusa, Andrew
Navaratnam, Naveenan
Adejumo, Thomas
Carling, David
Gottlieb, Eyal
Aboagye, Eric O.

May 2016

The glycerophospholipid phosphatidylcholine is the most abundant phospholipid species of eukaryotic ...

Therapeutic Potential of Modulating Glycogen Synthase Kinase 3 Activity in Tumor Cell-lines

Kumar, Megha

March 2021

Glycogen synthase kinase3 (GSK3) is a constitutively active serine/theronine kinasethat has two isof...

GSK-3 Inhibition: A Novel Approach to Sensitization of Chemo-resistant Pancreatic Cancer Cells

Mamaghani, Shadi

August 2011

The aggressive nature of pancreatic cancer, characterized by invasiveness, resistance to treatment, ...

Quantitative 31P HR-MAS MR spectroscopy for detection of response to PI3K/mTOR inhibition in breast cancer xenografts

Esmaeili, Morteza
Bathen, Tone Frost
Engebråten, Olav
Mælandsmo, Gunhild
Gribbestad, Ingrid S
Moestue, Siver Andreas

January 2014

PURPOSE: Phospholipid metabolites are of importance in cancer studies, and have been suggested as c...

Inhibition of GSK-3 induces differentiation and impaired glucose metabolism in renal cancer

Pal, K.
Cao, Y.
Gaisina, I.
Bhattacharya, S.
Dutta, S.
Wang, E.
Gunosewoyo, Hendra
Kozikowski, A.
Billadeau, D.
Mukhopadhyay, D.

January 2014

Glycogen synthase kinase-3 (GSK-3), a constitutively active serine/threonine kinase, is a key regula...

Metabolic changes in glioblastomas in response to choline kinase inhibition: In vivo MRS in rodent models

Bhaduri, Sourav
Kelly, Claire Louise
Lesbats, Clementine
Sharkey, Jack
Ressel, Lorenzo
Mukherjee, Soham
Platt, Mark David
Delikatny, Edward J
Poptani, Harish

January 2022

Changes in glioblastoma (GBM) metabolism was investigated in response to JAS239, a choline kinase in...

Inhibition of GSK-3β activity attenuates proliferation of human colon cancer cells in rodents

Shakoori Abbas
Mai Wei
Miyashita Katsuyoshi
Yasumoto Kazuo
Takahashi Yutaka
Ooi Akishi
Kawakami Kazuyuki
Minamoto Toshinari

September 2007

The authors\u27 recent discovery that glycogen synthase kinase-3β (GSK-3β) participates in colon can...

Combination treatment of cancer cells with pan-Akt and pan-mTOR inhibitors : effects on cell cycle distribution, p-Akt expression level and radiolabelled-choline incorporation

Phyu, Su Myat
Smith, Tim A. D.

June 2019

Open Access via Springer Compact Agreement Acknowledgements The University of Aberdeen Development T...

17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2

Brandes, Alissa H
Ward, Christopher S
Ronen, Sabrina M

October 2010

Abstract Introduction 17-allyamino-17-demethoxygeldanamycin (17-AAG), a small molecule inhibitor of ...

Activation of phosphatidylcholinespecific phospholipase C in breast and ovarian cancer: Impact on mrs-detected choline metabolic profile and perspectives for targeted therapy

F. Podo
L. Paris
S. Cecchetti
F. Spadaro
L. Abalsamo
C. Ramoni
A. Ricci
M.E. Pisanu
F. Sardanelli
R. Canese
E. Iorio

August 2016

Elucidation of molecular mechanisms underlying the aberrant phosphatidylcholine cycle in cancer cell...

The Effect of Antitumor Glycosides on Glioma Cells and Tissues as Studied by Proton HR-MAS NMR Spectroscopy

García-Álvarez, Isabel
Garrido, Leoncio
Romero-Ramírez, Lorenzo
Nieto-Sampedro, Manuel
Fernández-Mayoralas, Alfonso
Campos-Olivas, Ramón

December 2014

The effect of the treatment with glycolipid derivatives on the metabolic profile of intact glioma ce...

CDP-choline accumulation in breast and colorectal cancer cells treated with a GSK-3-targeting inhibitor

Abstract

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