This bachelor’s thesis focuses on a description of the interest rate models that are applied in the sphere of financial mathematics. Furthermore, it specifically describes the Vašíček model, Cox-Ingersoll-Ross model, Ho-Lee model and Hull-White model. These models are given by the stochastic differential equations. The main terms of the Stochastic Calculus are described in the theoretical part of the thesis. All the above models are also calibrated. Moreover, the spot and forward interbank interest rate—LIBOR is described in the thesis. By applying specific data, that are available in the public database of the Czech National Bank, we have simulated the Vašíček and Cox-Ingersoll-Ross models. The obtained results are interpreted