Hemichannel blockers in an artificial bilayer environment.

<p>(A) The addition of Heptanol to conducting Cx43 hemichannels terminated ionic current. (B) The addition of Carbenoxolone had no effect on open Cx43 hemichannels. (C) Lanthanum blocked current flowing through a collective aggregate of Cx43 hemichannels. (D) Lanthanum also blocked current flowing through a collective aggregate of Cx43eGFP hemichannels. (E) Lanthanum did not decrease current flowing through a single Cx43 hemichannel. (F) Lindane had no effect on the conductance of Cx43 hemichannels when added to the chamber.