Glomerular cells and matrix in ERα knockout mice.

<p>Compared to heterozygeous and wild-type animals, podocyte numbers were significantly reduced (A) and podocyte volume significantly increased (B) in ERα knockout animals. Mesangial cell number and volume showed the same tendencies, but reached significance only in some of the intergroup comparisons (A, B). Tgfβ1 and Collagen type IV expression is increased in KO animals (C, D). n = 6 animals per treatment group. ^a p<0.05 vs. femaleWT, ^b p<0.05 vs. maleWT, ^c p<0.05 vs. femaleHetero, ^d p<0.05 vs. maleHetero, ^e p<0.05 vs. femaleKO, ^f p<0.05 vs. maleKO. ANOVA with Tamhane post-hoc analysis (p<0.01).