Effect of the Bystander Proliferation of the Latent Reservoir on the Latent Reservoir and on Plasma Viral Load

<div><p>When there is no ongoing viral replication (ɛ = 1) and the minimum activation rate of the latent reservoir is zero (<i>a</i>_min = 0). The open circles indicate the decay kinetics of the latent reservoir suggested by Strain et al. [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0020135#pcbi-0020135-b030" target="_blank">30</a>], where they found t_1/2 ≈ 18 wk up to week 35 and t_1/2 ≈ 58 wk for the subsequent 3 y. The solid curve with <i>r</i> = −0.00171 d⁻¹ and ω = 0.00939 d⁻¹ represents the best-fit curve to the data.</p><p>(A) Latent reservoir.</p><p>(B) Plasma viral load.</p>