<p>HEK293T cells co-expressing ORF74-Rluc8 and β-arrestin1-eYFP (A, C) or β-arrestin2-eYFP (B, D) were stimulated with increasing concentrations of CXCL1 (open squares), CXCL8 (filled squares) or CXCL10 (open circles) (A, B) or co-stimulated with CXCL1 and CXCL10 (C, D). β-arrestin recruitment to the receptor was measured as an increase in BRET ratio (BRETr). Data are shown as fold over basal and represent the mean of pooled data from at least three independent experiments each performed in triplicate. Error bars indicate SEM values. Significant differences between vehicle and chemokine-stimulation were determined by one-way ANOVA followed by a Bonferroni test (**** p ≤ 0.0001). NS = not significant.</p
Based on heterodimerization of chemokine receptors CXCR4 and CCR5 with β-arrestin 1 in co-expressing...
<p>HEK293T cells were transiently transfected with ORF74-Rluc8 (WT) (A-D) or ORF74-ST/A2-Rluc8 (ST/A...
<p>Poster presented on May 31st, 2013, at the 18th annual symposium of Immuno-Inflamation, Eastman, ...
<p>(A, B) HEK293T cells were transiently transfected with WT-ORF74 (WT), ORF74-R<sup>3.50</sup>A (R<...
<p>(A) Schematic representation of the C-tail of ORF74, starting at the conserved VPxxY-motif in TM7...
<p>HEK293T cells were transiently transfected with ORF74-Rluc8 and Venus-K-Ras (plasma membrane mark...
<p>(A to C) Figures display that over-expressing β-arrestin 2 increases ligand-induced β-arrestin 2-...
<div><p>Chemokine CXCL12 promotes growth and metastasis of more than 20 different human cancers, as ...
Chemokine CXCL12 promotes growth and metastasis of more than 20 different human cancers, as well as ...
<p><b>A.</b> Real-time measurement of BRET signal in HEK293T cells expressing either β-arrestin1-<i>...
Chemokine CXCL12 promotes growth and metastasis of more than 20 different human cancers, as well as ...
<p>(<b>A</b>) CXCL11 or CXCL12-mediated β-arrestin2 recruitment to CXCR7. HEK293T co-expressing RLuc...
<p>(A and B) Model outputs for CXCL12-dependent recruitment of β-arrestin 2 specifically to CXCR4 (A...
Kaposi's sarcoma-associated herpesvirus-infected cells express the virally encoded G protein-coupled...
<div><p>Kaposi’s sarcoma-associated herpesvirus-infected cells express the virally encoded G protein...
Based on heterodimerization of chemokine receptors CXCR4 and CCR5 with β-arrestin 1 in co-expressing...
<p>HEK293T cells were transiently transfected with ORF74-Rluc8 (WT) (A-D) or ORF74-ST/A2-Rluc8 (ST/A...
<p>Poster presented on May 31st, 2013, at the 18th annual symposium of Immuno-Inflamation, Eastman, ...
<p>(A, B) HEK293T cells were transiently transfected with WT-ORF74 (WT), ORF74-R<sup>3.50</sup>A (R<...
<p>(A) Schematic representation of the C-tail of ORF74, starting at the conserved VPxxY-motif in TM7...
<p>HEK293T cells were transiently transfected with ORF74-Rluc8 and Venus-K-Ras (plasma membrane mark...
<p>(A to C) Figures display that over-expressing β-arrestin 2 increases ligand-induced β-arrestin 2-...
<div><p>Chemokine CXCL12 promotes growth and metastasis of more than 20 different human cancers, as ...
Chemokine CXCL12 promotes growth and metastasis of more than 20 different human cancers, as well as ...
<p><b>A.</b> Real-time measurement of BRET signal in HEK293T cells expressing either β-arrestin1-<i>...
Chemokine CXCL12 promotes growth and metastasis of more than 20 different human cancers, as well as ...
<p>(<b>A</b>) CXCL11 or CXCL12-mediated β-arrestin2 recruitment to CXCR7. HEK293T co-expressing RLuc...
<p>(A and B) Model outputs for CXCL12-dependent recruitment of β-arrestin 2 specifically to CXCR4 (A...
Kaposi's sarcoma-associated herpesvirus-infected cells express the virally encoded G protein-coupled...
<div><p>Kaposi’s sarcoma-associated herpesvirus-infected cells express the virally encoded G protein...
Based on heterodimerization of chemokine receptors CXCR4 and CCR5 with β-arrestin 1 in co-expressing...
<p>HEK293T cells were transiently transfected with ORF74-Rluc8 (WT) (A-D) or ORF74-ST/A2-Rluc8 (ST/A...
<p>Poster presented on May 31st, 2013, at the 18th annual symposium of Immuno-Inflamation, Eastman, ...