The schematic structure and the mutations of the human myosin XVa.

<p>The myosin XVa consists of 3530 amino acids, including an N-terminal extension domain and Motor domain, two light chain binding IQ motifs, two myosin-tail homology 4 (MyTH4) domains and band 4.1/ezrin/radixin/moesin (FERM) domains, a Src-homology-3 (SH3) domain and a C-terminal class I PDZ-ligand domain. The novel <i>MYO15A</i> mutation in this study is showed with red box at the bottom of the figure, and previously reported mutations are displayed at the top of the figure. <i>MYO15A</i>, the myosin XVa gene.