Despite the interest and diversity of the pharmacological properties of 2,5-diketopiperazines (DKPs), the biosynthetic pathways of these microbial molecules are poorly documented. The aim of my doctoral work was i) to identify new DKP biosynthetic pathways that are characterized by the presence of a cyclodipeptide synthase (CDPS) often associated with one or more cyclodipeptide-tailoring enzymes and ii) to explore the chemical diversity encoded by these pathways. First of all, my study focused on CDPSs. After the bioinformatics-based selection of candidates, 51 novel CDPS were characterized, revealing the incorporation of 17 of the 20 proteinogenic amino acids. Moreover, this work has allowed a better characterization of the CDPS family, by...
Les métabolites dérivés des dicétopipérazines (DKP), essentiellement produits par les micro-organism...
Cyclic depsipeptides, ubiquitous natural products of industrial and medical importance, are produced...
AbstractAlbonoursin [cyclo(ΔPhe-ΔLeu)], an antibacterial peptide produced by Streptomyces noursei, i...
Diketopiperazines (DKP) are a class of natural products widely used in medicine. In producer organis...
Cyclodipeptides and their derivatives, the diketopiperazines (DKPs), constitute a large class of sec...
Les dicétopipérazines (DKP : diketopiperazines) sont une classe de produits naturels largement utili...
Les cyclodipeptides et leurs dérivés, les dicétopipérazines (DKP), constituent une large classe de m...
International audienceAbstract Background Cyclodipeptide oxidases (CDOs) are enzymes involved in the...
International audienceThe manipulation of natural product biosynthetic pathways is a powerful means ...
Modified cyclic dipeptides represent a diverse family of microbial secondary metabolites. They displ...
Cyclodipeptides and their complex derivatives, the diketopiperazines (DKPs), constitute a large clas...
International audienceCyclodipeptide synthases (CDPSs) use as substrates two amino acids activated a...
International audienceWe review here work on the biosynthesis of diketopiperazines (DKPs), a large c...
Secondary metabolites originated from plants, bacteria and fungi constitute a large group of compoun...
A large number of bioactive natural products containing a 2,5-diketopiperazine (DKP) moiety have bee...
Les métabolites dérivés des dicétopipérazines (DKP), essentiellement produits par les micro-organism...
Cyclic depsipeptides, ubiquitous natural products of industrial and medical importance, are produced...
AbstractAlbonoursin [cyclo(ΔPhe-ΔLeu)], an antibacterial peptide produced by Streptomyces noursei, i...
Diketopiperazines (DKP) are a class of natural products widely used in medicine. In producer organis...
Cyclodipeptides and their derivatives, the diketopiperazines (DKPs), constitute a large class of sec...
Les dicétopipérazines (DKP : diketopiperazines) sont une classe de produits naturels largement utili...
Les cyclodipeptides et leurs dérivés, les dicétopipérazines (DKP), constituent une large classe de m...
International audienceAbstract Background Cyclodipeptide oxidases (CDOs) are enzymes involved in the...
International audienceThe manipulation of natural product biosynthetic pathways is a powerful means ...
Modified cyclic dipeptides represent a diverse family of microbial secondary metabolites. They displ...
Cyclodipeptides and their complex derivatives, the diketopiperazines (DKPs), constitute a large clas...
International audienceCyclodipeptide synthases (CDPSs) use as substrates two amino acids activated a...
International audienceWe review here work on the biosynthesis of diketopiperazines (DKPs), a large c...
Secondary metabolites originated from plants, bacteria and fungi constitute a large group of compoun...
A large number of bioactive natural products containing a 2,5-diketopiperazine (DKP) moiety have bee...
Les métabolites dérivés des dicétopipérazines (DKP), essentiellement produits par les micro-organism...
Cyclic depsipeptides, ubiquitous natural products of industrial and medical importance, are produced...
AbstractAlbonoursin [cyclo(ΔPhe-ΔLeu)], an antibacterial peptide produced by Streptomyces noursei, i...