Inhibition of RNA recruitment and replication of an RNA virus by acridine derivatives with known anti-prion activitie
Le prion est un agent pathogène infectieux de nature protéique responsable de maladies neurodégénéra...
International audienceUsing a yeast-based assay, a previously unsuspected antiprion activity was fou...
No validated treatments exist for transmissible spongiform encephalopathies (TSEs or prion diseases)...
Background: Small molecule inhibitors of RNA virus replication are potent antiviral drugs and useful...
Quinacrine is one of the few molecules tested to treat patients affected by prion diseases, although...
Prion diseases, including sheep scrapie, are neurodegenerative diseases with the fundamental pathoge...
<p>Inhibition potency of ALS-8112-TP against RSV and other viral RNA polymerases.</p
Transmissible spongiform encephalopathies (TSEs) are thought to arise from aggregation of a protease...
Prion propagation is mediated by the structural alteration of normal prion protein (PrPC) to generat...
The SAR development is described for a series of N-acyl pyrrolidine inhibitors of the Hepatitis C vi...
RNA-dependent RNA polymerase (RdRP) is essential for the replication and expression of RNA viral gen...
2-Aminopyridine-3,5-dicarbonitrile compounds were previously identified as mimetics of dominant-nega...
[[abstract]]The aim of this study was to identify the antiviral mechanism of a novel compound, BPR3P...
Acridines are known deoxyribonucleic acid (DNA) intercalators. Accordingly, the interaction of the p...
DNA/RNA intercalating agents are compounds with capability to insert themself between nucleic acids ...
Le prion est un agent pathogène infectieux de nature protéique responsable de maladies neurodégénéra...
International audienceUsing a yeast-based assay, a previously unsuspected antiprion activity was fou...
No validated treatments exist for transmissible spongiform encephalopathies (TSEs or prion diseases)...
Background: Small molecule inhibitors of RNA virus replication are potent antiviral drugs and useful...
Quinacrine is one of the few molecules tested to treat patients affected by prion diseases, although...
Prion diseases, including sheep scrapie, are neurodegenerative diseases with the fundamental pathoge...
<p>Inhibition potency of ALS-8112-TP against RSV and other viral RNA polymerases.</p
Transmissible spongiform encephalopathies (TSEs) are thought to arise from aggregation of a protease...
Prion propagation is mediated by the structural alteration of normal prion protein (PrPC) to generat...
The SAR development is described for a series of N-acyl pyrrolidine inhibitors of the Hepatitis C vi...
RNA-dependent RNA polymerase (RdRP) is essential for the replication and expression of RNA viral gen...
2-Aminopyridine-3,5-dicarbonitrile compounds were previously identified as mimetics of dominant-nega...
[[abstract]]The aim of this study was to identify the antiviral mechanism of a novel compound, BPR3P...
Acridines are known deoxyribonucleic acid (DNA) intercalators. Accordingly, the interaction of the p...
DNA/RNA intercalating agents are compounds with capability to insert themself between nucleic acids ...
Le prion est un agent pathogène infectieux de nature protéique responsable de maladies neurodégénéra...
International audienceUsing a yeast-based assay, a previously unsuspected antiprion activity was fou...
No validated treatments exist for transmissible spongiform encephalopathies (TSEs or prion diseases)...
View in ORKG