Background: Type 2 diabetes is characterized by pancreatic beta-cell dysfunction and is associated with low-grade inflammation. Recent observations suggest that apoptosis signal-regulating kinase 1 (ASK1) is involved in beta-cell death in response to different stressors. In this study, we tested whether ASK1 deficiency protects beta-cells from glucolipotoxic conditions and cytokines treatment or from glucose homeostasis alteration induced by endotoxemia. Methodology/Principal Findings: Insulin secretion was neither affected upon shRNA-mediated downregulation of ASK1 in MIN6 cells nor in islets from ASK1-deficient mice. ASK1 silencing in MIN6 cells and deletion in islets did not prevent the deleterious effect of glucolipotoxic conditions or ...
To characterize the differentiation events that selectively target insulin-producing cells to interl...
Apoptosis is probably the main form of beta-cell death in both type 1 diabetes mellitus (T1DM) and T...
Objective—The pathogenic role of macrophage apoptosis in atherosclerosis is still debatable, but it ...
BACKGROUND:Type 2 diabetes is characterized by pancreatic beta-cell dysfunction and is associated wi...
Type 2 diabetes is characterized by pancreatic beta-cell dysfunction and is associated with low-grad...
Pancreatic beta-cell dysfunction and insulin resistance are two interrelated defects in the pathophy...
<p>(A) Insulin secretion in response to 2 and 20 mM glucose in MIN6 shCTL and shASK1cells pre-incuba...
Apoptosis signal-regulating kinase-1 (ASK1) is a mitogen-activated protein 3 kinase (MAPKKK/MAP3K) w...
<p>MIN6 shCTL and shASK1 cells survival (A) and apoptosis (B) in response to thapsigargin (0.5 µM) o...
Apoptosis signal-regulating kinase-1 (ASK1) is a mitogen-activated protein 3 kinase (MAPKKK/MAP3K) w...
Aims/hypothesis: Proinflammatory cytokines contribute to beta cell destruction in type 1 diabetes, b...
AIMS/HYPOTHESIS: Proinflammatory cytokines contribute to beta cell destruction in type 1 diabetes, b...
ABSTRACT Aims/hypotheses: The two main forms of diabetes, type 1 and type 2, are characterised by pr...
AIMS/HYPOTHESIS: Wolfram syndrome is an autosomal recessive disorder characterised by childhood diab...
Diabetes is a disease of insufficient insulin production from pancreatic beta cells. This arises as ...
To characterize the differentiation events that selectively target insulin-producing cells to interl...
Apoptosis is probably the main form of beta-cell death in both type 1 diabetes mellitus (T1DM) and T...
Objective—The pathogenic role of macrophage apoptosis in atherosclerosis is still debatable, but it ...
BACKGROUND:Type 2 diabetes is characterized by pancreatic beta-cell dysfunction and is associated wi...
Type 2 diabetes is characterized by pancreatic beta-cell dysfunction and is associated with low-grad...
Pancreatic beta-cell dysfunction and insulin resistance are two interrelated defects in the pathophy...
<p>(A) Insulin secretion in response to 2 and 20 mM glucose in MIN6 shCTL and shASK1cells pre-incuba...
Apoptosis signal-regulating kinase-1 (ASK1) is a mitogen-activated protein 3 kinase (MAPKKK/MAP3K) w...
<p>MIN6 shCTL and shASK1 cells survival (A) and apoptosis (B) in response to thapsigargin (0.5 µM) o...
Apoptosis signal-regulating kinase-1 (ASK1) is a mitogen-activated protein 3 kinase (MAPKKK/MAP3K) w...
Aims/hypothesis: Proinflammatory cytokines contribute to beta cell destruction in type 1 diabetes, b...
AIMS/HYPOTHESIS: Proinflammatory cytokines contribute to beta cell destruction in type 1 diabetes, b...
ABSTRACT Aims/hypotheses: The two main forms of diabetes, type 1 and type 2, are characterised by pr...
AIMS/HYPOTHESIS: Wolfram syndrome is an autosomal recessive disorder characterised by childhood diab...
Diabetes is a disease of insufficient insulin production from pancreatic beta cells. This arises as ...
To characterize the differentiation events that selectively target insulin-producing cells to interl...
Apoptosis is probably the main form of beta-cell death in both type 1 diabetes mellitus (T1DM) and T...
Objective—The pathogenic role of macrophage apoptosis in atherosclerosis is still debatable, but it ...