Research Article Harmine andHarmaline Downregulate TCDD-Induced Cyp1a1 in the Livers and Lungs of C57BL/6Mice

Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We previously demonstrated that Peganum harmala L. extract and its main active constituents, harmine and harmaline inhibit the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated induction of the carcinogen-activating enzyme, Cyp1a1, in vitro. However, the effect of both alkaloids on Cyp1a1 in vivo has not been investigated. erefore, the aim of this study is to examine the effect of harmine and harmaline on TCDD-mediated induction of Cyp1a1 in mice livers and lungs. C57BL/6 male mice were distributed into four groups