Neuron Article Cerebellar LTD and Pattern Recognition by

  • Purkinje Cells
  • Volker Steuber
  • Wolfgang Mittmann
  • Freek E. Hoebeek
  • R. Angus Silver
  • Chris I. De Zeeuw
  • Erik De Schutter
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Publication date
January 2015

Abstract

Many theories of cerebellar function assume that long-term depression (LTD) of parallel fiber (PF) synapses enables Purkinje cells to learn to recognize PF activity patterns. We have studied the LTD-based recognition of PF patterns in a biophysically realistic Purkinje-cell model. With simple-spike firing as observed in vivo, the presentation of a pattern resulted in a burst of spikes followed by a pause. Surprisingly, the best criterion to distinguish learned patterns was the duration of this pause. Moreover, our simulations predicted that learned patterns elicited shorter pauses, thus increasing Purkinje-cell output. We tested this prediction in Purkinje-cell recordings both in vitro and in vivo. In vitro, we found a shortening of pauses ...

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