Many theories of cerebellar function assume that long-term depression (LTD) of parallel fiber (PF) synapses enables Purkinje cells to learn to recognize PF activity patterns. We have studied the LTD-based recognition of PF patterns in a biophysically realistic Purkinje-cell model. With simple-spike firing as observed in vivo, the presentation of a pattern resulted in a burst of spikes followed by a pause. Surprisingly, the best criterion to distinguish learned patterns was the duration of this pause. Moreover, our simulations predicted that learned patterns elicited shorter pauses, thus increasing Purkinje-cell output. We tested this prediction in Purkinje-cell recordings both in vitro and in vivo. In vitro, we found a shortening of pauses ...
In vitro studies have supported the occurrence of cerebellar long-term depression (LTD), an interact...
In vitro studies have supported the occurrence of cerebellar long-term depression (LTD), an interact...
AbstractIn classic Marr-Albus-Ito models of cerebellar function, coactivation of the climbing fiber ...
Many theories of cerebellar function assume that long-term depression (LTD) of parallel fiber (PF) s...
SummaryMany theories of cerebellar function assume that long-term depression (LTD) of parallel fiber...
Many theories of cerebellar function assume that long-term depression (LTD) of parallel fiber (PF) s...
Many theories of cerebellar learning assume that long-term depression (LTD) of synapses between para...
Full text of this article is not available in the UHRAIt has been suggested that long-term depressio...
“The original publication is available at www.springerlink.com”. Copyright Springer.Many cerebellar ...
Purkinje-cell output. We tested this prediction many theoretical studies of cerebellar learning (for...
Traditionally, the function of the cerebellum has been thought to be associated with motor control o...
Long-term depression (LTD) of parallel fibre/Purkinje cell synapses has been the favoured explanatio...
Long-term depression (LTD) of parallel fibre/Purkinje cell synapses has been the favoured explanatio...
We develop a new model that explains how the cerebellum may generate the timing in classical delay e...
In vitro studies have supported the occurrence of cerebellar long-term depression (LTD), an interact...
In vitro studies have supported the occurrence of cerebellar long-term depression (LTD), an interact...
In vitro studies have supported the occurrence of cerebellar long-term depression (LTD), an interact...
AbstractIn classic Marr-Albus-Ito models of cerebellar function, coactivation of the climbing fiber ...
Many theories of cerebellar function assume that long-term depression (LTD) of parallel fiber (PF) s...
SummaryMany theories of cerebellar function assume that long-term depression (LTD) of parallel fiber...
Many theories of cerebellar function assume that long-term depression (LTD) of parallel fiber (PF) s...
Many theories of cerebellar learning assume that long-term depression (LTD) of synapses between para...
Full text of this article is not available in the UHRAIt has been suggested that long-term depressio...
“The original publication is available at www.springerlink.com”. Copyright Springer.Many cerebellar ...
Purkinje-cell output. We tested this prediction many theoretical studies of cerebellar learning (for...
Traditionally, the function of the cerebellum has been thought to be associated with motor control o...
Long-term depression (LTD) of parallel fibre/Purkinje cell synapses has been the favoured explanatio...
Long-term depression (LTD) of parallel fibre/Purkinje cell synapses has been the favoured explanatio...
We develop a new model that explains how the cerebellum may generate the timing in classical delay e...
In vitro studies have supported the occurrence of cerebellar long-term depression (LTD), an interact...
In vitro studies have supported the occurrence of cerebellar long-term depression (LTD), an interact...
In vitro studies have supported the occurrence of cerebellar long-term depression (LTD), an interact...
AbstractIn classic Marr-Albus-Ito models of cerebellar function, coactivation of the climbing fiber ...