Spherical crystallization: a tool of particle engineering for making drug powder suitable for direct compression

Spherical crystallization is the novel agglomerated technique that can directly transform the fine crystals produced in the crystallization process into a spherical shape. It is the particle engineering technique by which crystallization and agglomeration can be carried out simultaneously in one step to transform crystals directly into compacted spherical form. This technique of particle design of drugs has emerged as one the areas of active research currently of interest in pharmaceutical manufacturing and recently came into the forefront of interest or gained interest due to the fact that crystal habit can be modified during crystallization process which would result in better micrometric properties like particle size those can enhance the flowability of the powder drug and prepared spherical crystals can be compress directly without performing granulation, drying and so many steps those are require in wet granulation and in dry granulation process of tablet manufacturing