Diffusional Kurtosis Imaging Assessment of Tuberous Sclerosis Complex

Tuberous sclerosis complex (TSC) is a rare, multi-system genetic disease that, as a result of dominant mutations of TSC1 and TSC2 genes, causes tumors/lesions to grow in various organs. In the central nervous system, TSC is predominantly characterized by cortical/subcortical tubers which are responsible for the seizures (90%) and mild to severe developmental delays found in TSC [1]. Although tuber lesions are presumed to contribute to epileptogenesis in TSC, a few studies have identifie