Purcaro A. Randomized, controlled trial of long-term moderate exercise training in chronic heart failure: effects on functional capacity, quality of life, and clinical outcome. Circulation

Background—It is still a matter of debate whether exercise training (ET) is a beneficial treatment in chronic heart failure (CHF). Methods and Results—To determine whether long-term moderate ET improves functional capacity and quality of life in patients with CHF and whether these effects translate into a favorable outcome, 110 patients with stable CHF were initially recruited, and 99 (59614 years of age; 88 men and 11 women) were randomized into 2 groups. One group (group T, n550) underwent ET at 60 % of peak V ˙ O2, initially 3 times a week for 8 weeks, then twice a week for 1 year. Another group (group NT, n549) did not exercise. At baseline and at months 2 and 14, all patients underwent a cardiopulmonary exercise test, while 74 patients (37 in group T and 37 in group NT) with ischemic heart disease underwent myocardial scintigraphy. Quality of life was assessed by questionnaire. Ninety-four patients completed the protocol (48 in group T and 46 in group NT). Changes were observed only in patients in group T. Both peak V ˙ O2 and thallium activity score improved at 2 months (18 % and 24%, respectively; P,0.001 for both) and did not change further after 1 year. Quality of life also improved and paralleled peak V ˙ O2. Exercise training was associated both with lower mortality (n59 versus n520 for those with training versus those without; relative risk (RR)50.37; 95 % CI, 0.17 to 0.84; P50.01) and hospital readmission for heart failure (5 versus 14; RR50.29; 95 % CI, 0.11 to 0.88; P50.02). Independent predictors of events were ventilatory threshold at baseline (b-coefficient50.378) and posttraining thallium activity scor