Developmental Regulation of B Lymphocyte Immune Tolerance Compartmentalizes Clonal Selection from Receptor Selection

1995) resulting in down-regulation of V(D)J recombina-tion that prevents further H chain rearrangements and insures ªallelic exclusion,º i.e., that the B cell expresses only one of its two potential H chain gene alleles (Storb et al., 1994). PreBCR signaling also results in a burs