Add to ORKGBased on the encouraging results, we report the multistep synthesis and the biologicalo results of two new analogs of tetrazepinones: the 3,5-dimethyl-6-phenyl-8-(trifluoromethyl-5,6-dihydropyrazo1o[3-4-f]1,2,35)tetrazepin-4(3H)-one and the 3-(2-chloroethyl)-5-methyl-6-phenyl-8-(trifluoromethyl-5,6-dihydropyrazo1o[3-4-f]1,2,35)tetrazepin-4(3H)-one. Both compounds showed a pro-apoptotic activity against HL60 and K562 resistant cell lines. Flow cytometry studies carried out 0n K562 cells allowed to establish that the methyl derivative induces G0-G1, phase arrest followed by apoptosis, whereas the chloroethyl derivative is a not phase-specific agent
By reacting methylaminopyrazoles with hexane-2,5-dione in 1,4-dioxane in the presence of p-toluensul...
The aryl tetralone as potential antimitotic agents were synthesized in four step reactions using Gri...
A new series of novel 7-hydroxy-4-phenylchromen-2-one (1a)–linked 1,2,4-triazoles were synthesised u...
Based on the encouraging results, we report the multistep synthesis and the biologicalo results of t...
Based on the encouraging results found for 3,5-dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyra...
The multistep synthesis of 3,5-dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,...
The multistep synthesis of two pyrazolo[3,4-f][1,2,3,5]tetrazepin-4(3H)-one derivatives, a new class...
In order to investigate their anticancer potential, four new pyrazolo[1,2-a]benzo[1,2,3,4]tetrazinon...
In order to develop a novel analog of the antitumour agent Mitozolomide 1, the diazotization of a va...
We have synthesized four novel derivatives of podophyllotoxin, the chalcone derivatives n...
In recent years, besides the main field of nonsteroidal anti-inflammatory agents, the interest towar...
The reaction under reflux between 1-phenyl-3-R-5-methylaminopyrazoles and 2,5-hexanedione lead to 5,...
Tubulin, the major structural component of microtubules, is a target for the development of anticanc...
Podophyllotoxin is a natural product isolated from two important medicinal plants podophyllum emodi ...
1-Methylpyrazolo[1,2-a]benzo[1,2,3,4]tetrazin-3-ones 4, synthesized in good to excellent yields, we...
By reacting methylaminopyrazoles with hexane-2,5-dione in 1,4-dioxane in the presence of p-toluensul...
The aryl tetralone as potential antimitotic agents were synthesized in four step reactions using Gri...
A new series of novel 7-hydroxy-4-phenylchromen-2-one (1a)–linked 1,2,4-triazoles were synthesised u...
Based on the encouraging results, we report the multistep synthesis and the biologicalo results of t...
Based on the encouraging results found for 3,5-dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyra...
The multistep synthesis of 3,5-dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,...
The multistep synthesis of two pyrazolo[3,4-f][1,2,3,5]tetrazepin-4(3H)-one derivatives, a new class...
In order to investigate their anticancer potential, four new pyrazolo[1,2-a]benzo[1,2,3,4]tetrazinon...
In order to develop a novel analog of the antitumour agent Mitozolomide 1, the diazotization of a va...
We have synthesized four novel derivatives of podophyllotoxin, the chalcone derivatives n...
In recent years, besides the main field of nonsteroidal anti-inflammatory agents, the interest towar...
The reaction under reflux between 1-phenyl-3-R-5-methylaminopyrazoles and 2,5-hexanedione lead to 5,...
Tubulin, the major structural component of microtubules, is a target for the development of anticanc...
Podophyllotoxin is a natural product isolated from two important medicinal plants podophyllum emodi ...
1-Methylpyrazolo[1,2-a]benzo[1,2,3,4]tetrazin-3-ones 4, synthesized in good to excellent yields, we...
By reacting methylaminopyrazoles with hexane-2,5-dione in 1,4-dioxane in the presence of p-toluensul...
The aryl tetralone as potential antimitotic agents were synthesized in four step reactions using Gri...
A new series of novel 7-hydroxy-4-phenylchromen-2-one (1a)–linked 1,2,4-triazoles were synthesised u...