Randomized clinical trials (RCTs) are performed to provide evidence to support treatment decisions. Based on the nature of those studies and the need to avoid confounding factors, it has been argued that the population selected in RCTs only partially represents the real-life population. This assumption casts doubts on the applicability of the results provided by RCTs in the management of individuals with an established diagnosis of COPD, and advocates the need for complementary studies with a pragmatic design. Herein, we comment on the recent article published by Halpin and colleagues on the Journal [Halpin et al, Respir Res 17:120, 2016], in which higher rates of inclusions in RCTs for COPD are found compared to previous observations. By a...
Acknowledgements We thank Dr Ruth B Murray (Medscript NZ Ltd) and Celine Goh, MBBS for their assista...
Real-world data provide the potential for generating evidence on drug treatment effects in groups ex...
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a progressive disease affecting 3 mill...
Randomized clinical trials (RCTs) are performed to provide evidence to support treatment decisions. ...
Abstract Randomized clinical trials (RCTs) are performed to provide evidence to suppo...
Management guidelines of chronic obstructive pulmonary disease (COPD) are mainly based on results of...
Acknowledgments The authors wish to acknowledge Derek Skinner with gratitude for his assistance with...
SummaryBackgroundCOPD is a heterogeneous disease comprising a wide range of clinical phenotypes, dep...
International audienceBackgroundIn patients with chronic obstructive pulmonary disease, all efforts ...
BACKGROUND AND OBJECTIVE: We aimed to explore to what extent an unselected population of chronic obs...
Objective To investigate the external validity of six large randomized controlled medication trials ...
Objective To investigate the external validity of six large randomized controlled medication trials ...
Randomized Controlled Trials (RCTs) are the "gold standard" for evaluating treatment outcomes provid...
Rationale: Clinical trial eligibility criteria are employed to efficiently determine intervention ef...
Evidence-based medicine is a corner stone in treatment decision making and large randomised, clinica...
Acknowledgements We thank Dr Ruth B Murray (Medscript NZ Ltd) and Celine Goh, MBBS for their assista...
Real-world data provide the potential for generating evidence on drug treatment effects in groups ex...
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a progressive disease affecting 3 mill...
Randomized clinical trials (RCTs) are performed to provide evidence to support treatment decisions. ...
Abstract Randomized clinical trials (RCTs) are performed to provide evidence to suppo...
Management guidelines of chronic obstructive pulmonary disease (COPD) are mainly based on results of...
Acknowledgments The authors wish to acknowledge Derek Skinner with gratitude for his assistance with...
SummaryBackgroundCOPD is a heterogeneous disease comprising a wide range of clinical phenotypes, dep...
International audienceBackgroundIn patients with chronic obstructive pulmonary disease, all efforts ...
BACKGROUND AND OBJECTIVE: We aimed to explore to what extent an unselected population of chronic obs...
Objective To investigate the external validity of six large randomized controlled medication trials ...
Objective To investigate the external validity of six large randomized controlled medication trials ...
Randomized Controlled Trials (RCTs) are the "gold standard" for evaluating treatment outcomes provid...
Rationale: Clinical trial eligibility criteria are employed to efficiently determine intervention ef...
Evidence-based medicine is a corner stone in treatment decision making and large randomised, clinica...
Acknowledgements We thank Dr Ruth B Murray (Medscript NZ Ltd) and Celine Goh, MBBS for their assista...
Real-world data provide the potential for generating evidence on drug treatment effects in groups ex...
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a progressive disease affecting 3 mill...