abstract: Bismuth drugs, despite being clinically used for decades, surprisingly remain in use and effective for the treatment of Helicobacter pylori infection, even for resistant strains when co-administrated with antibiotics. However, the molecular mechanisms underlying the clinically sustained susceptibility of H. pylori to bismuth drugs remain elusive. Herein, we report that integration of in-house metalloproteomics and quantitative proteomics allows comprehensive uncovering of the bismuth-associated proteomes, including 63 bismuth-binding and 119 bismuth-regulated proteins from Helicobacter pylori, with over 60% being annotated with catalytic functions. Through bioinformatics analysis in combination with bioassays, we demonstrated that...
Bismuth has been used in medicine for over two centuries for the treatment of various diseases, in p...
HspA, a protein crucial for nickel homeostasis in Helicobacter pylori (H. pylori), has a unique hist...
A method that allows partial denaturation of protein ligands in Bi- and Zn-protein complexes, leavin...
Helicobacter pylori is a major human pathogen that can cause peptic ulcers and chronic gastritis. Bi...
International audienceBacterial antibiotic resistance is a major threat to human health. A combinati...
Session 5: Protein interaction, network and proteomicsProtein and beyondMetallomics and metalloprote...
Metallodrugs have been clinically utilized to treat various microbial infections for decades. Nevert...
Plenery Speech no. 271It is crucial to identify metal-protein interactions at a proteome-wide scale ...
Over 300 Bi-binding peptides from 166 proteins in H. pylori were identified by Bi-IMAC. Bi3+ exhibit...
Bismuth compounds have been widely used in the clinic for centuries because of their high effectiven...
Bismuth (Bi3+) binds equal molar amounts of HypB from Helicobacter pylori at the conserved metal si...
International audienceMetal acquisition and intracellular trafficking are crucial for all cells and ...
Bismuth compounds are widely used for the treatment of peptic ulcers and Helicobacter pylori infecti...
Cysteine and histidine residues are tempting donors for Ni(2+) which coordinates to the sulfur of Cy...
Glutathione and multidrug resistance protein (MRP) play an important role on the metabolism of a var...
Bismuth has been used in medicine for over two centuries for the treatment of various diseases, in p...
HspA, a protein crucial for nickel homeostasis in Helicobacter pylori (H. pylori), has a unique hist...
A method that allows partial denaturation of protein ligands in Bi- and Zn-protein complexes, leavin...
Helicobacter pylori is a major human pathogen that can cause peptic ulcers and chronic gastritis. Bi...
International audienceBacterial antibiotic resistance is a major threat to human health. A combinati...
Session 5: Protein interaction, network and proteomicsProtein and beyondMetallomics and metalloprote...
Metallodrugs have been clinically utilized to treat various microbial infections for decades. Nevert...
Plenery Speech no. 271It is crucial to identify metal-protein interactions at a proteome-wide scale ...
Over 300 Bi-binding peptides from 166 proteins in H. pylori were identified by Bi-IMAC. Bi3+ exhibit...
Bismuth compounds have been widely used in the clinic for centuries because of their high effectiven...
Bismuth (Bi3+) binds equal molar amounts of HypB from Helicobacter pylori at the conserved metal si...
International audienceMetal acquisition and intracellular trafficking are crucial for all cells and ...
Bismuth compounds are widely used for the treatment of peptic ulcers and Helicobacter pylori infecti...
Cysteine and histidine residues are tempting donors for Ni(2+) which coordinates to the sulfur of Cy...
Glutathione and multidrug resistance protein (MRP) play an important role on the metabolism of a var...
Bismuth has been used in medicine for over two centuries for the treatment of various diseases, in p...
HspA, a protein crucial for nickel homeostasis in Helicobacter pylori (H. pylori), has a unique hist...
A method that allows partial denaturation of protein ligands in Bi- and Zn-protein complexes, leavin...