Allergies, medications and their complications, in this context,

Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Lenka Březinová Supervisor: PharmDr. Petr Jílek, CSc. Title of bachelor thesis: Allergies, their complications and drugs in this context, early 21st century An allergy is one of the main health problems in major modern society. Although allergy is known for centuries, dramatic growth of incidence has been noticed in last decades. Discovery of immunoglobulin E as a carrier of direct hypersensitivity was an important progress in allergology. Allergic reactions are divided into six classes, which can diffuse each other. Clinical symptoms are predestined by mediators, which come from different cells. The best known is histamine, then leukotrienes, eicosanoids etc. Allergy can be complicated by rhinoconjuctivitis, chronic sinusitis, nasal polyps, middle ear inflammation, atopic eczema, and asthma or life threatening anaphylactic shock. Allergic symptoms are inhibited by antihistamines. There are two generation of these basic drugs. The next option to treat the allergy is the immunotherapy, which is the only one who has potential to avert or change process of allergic disease. However this treatment is very expensive. Allergy is worldwide epidemic with fast growing occurrence in..