Nanodispersion application system.

Diploma thesis summarizes the current information about the biopharmaceutical pharmaceutical classification system, disperse systems and solid dispersions in the field of drug delivery dosage forms. The experiment is directed to an in vitro dissolution evaluation of nanofibre membranes produced by electrospinning. The membranes contained a mixture of 10% bovine albumin and FICT albumin in a ratio of 1: 1 and further polyethylene oxide and polyvinyl alcohol. The main task was to verify the transmucosal in vitro permeation of albumin using sublingual membrane in vitro. The acceptor phase was phosphate buffer pH 7.4. The dissolution experiment confirmed a very rapid dissolution of the carrier nanofibrous membrane containing albumin. The most of the albumin was available for analysis already in 3, resp. 5 minutes. The time course of in vitro permeation of albumin through the sublingual porcine membrane showed 24 hr continuous linear period, either during permeation of nanofibrous membrane or a comparative solution. Average values of albumin fluxes under these conditions were ca J = 0.81 [ng / cm2 / h] SEM = 0,3 when 64layered nanomembrane and donor adjusted at pH 6.8, J = 0.40 [ng / cm2 / h], SEM = 0.34 or when nanomebrane was adjusted in donor at pH 7.4, and J = 0.77 [ng / cm 2 / h] for solution at pH..