Degradation of branched polyesters in the aqueous environment with various ionic strength

Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate: Anna Mecnerová Supervisor: Doc. RNDr. Milan Dittrich, CSc. Title of diploma thesis: Biodegradation of branched polyesthers in the aquous medium with various ionic force The thesis is focused on the degradation of branched polyesters in an aqueous medium with different ionic strength and is divided into theoretical and experimental part. The theoretical part deals mainly with the definition and properties of polymers, biodegradable polymers, aliphatic polyesters, branched aliphatic polyesters and their use in practice, derived from bibliographic records on the subject. In the experimental section examines the effect of ionic strength on the degradation of branched polyesters, namely three samples polymers T3 (branched on tripentaerythritol), and No. 73 and No. 74 branched on mannitol. Polymer matrix weighing 150mg swollen in phosphate buffer at various concentrations and in an aqueous medium at intervals of 1, 3, 7, 14, 21 days. Subsequently evaluated two basic parameters and swelling and erosion. Based on the graphs were evaluated branched polymers that swell in aqueous medium is lower than in an environment containing ions