Prodrug structures to improve the drug delivery of anti-cancer agents

Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Student: Vendula Králová Supervisor: Prof. PharmDr. Martin Doležal, Ph.D Specialized supervisor: Kristiina Huttunen, Ph.D Title of diploma thesis: Prodrug structures to improve the drug delivery of anti- cancer agents Cancer belongs to the most widespread diseases in the world, and we can expect that it will remain among the deadliest illnesses in the future. For this reason, scientists have put enormous efforts into researching new drugs, which would stop this growing trend. Nowadays, pharmaceutical research is focused mainly on the development of targeted treatment of oncological diseases, which aims at specific structures on the surface or in the core of the tumorous cells. This treatment is limited only to a precisely targeted group of tumors, and it usually leaves healthy cells unharmed. Through clinical studies, many new medications have been developed, and they show high efficiency in the treatment of various types of cancer. However, their success is constrained by drug resistance, which has become a significant obstacle to their use. The topic of this thesis is the synthesis of new anticancer drugs and their prodrugs. These prodrugs were prepared in such a way that they would..