The study of matrix tablets with two types of the Carbopol®

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department Pharmaceutical Technology Candidate Mgr. Marie Neprašová Consultant PharmDr. Jitka Mužíková, Ph.D. Title of the Thesis The study of matrix tablets with two types of the Carbopol® The thesis studies the compressibility of directly compressible tableting materials and the rate of drug release from tablets with two types of carbomers, powder Carbopol® 971P NF and granular Carbopol® 71G NF. The tested concentrations of the polymers in the tablets are 5, 10, 15 and 20 %. The compressibility is evaluated via energetic profile of the compression and tensile strength of the tablets. The values of total energy increased with the compression force and decreased with the growing concentration of both Carbopol® , more markedly in the case of powder Carbopol® . The powder Carbopol® provided stronger tablets than the granular form. The lowest concentration of Carbopol® 971P NF prolonged the release time of the salicylic acid more than the highest concentration of the Carbopol® 71G NF