Determination of flow properties of mixtures for preparation of tablets containing theophylline

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: Doc. PharmDr. Šklubalová Zdeňka, Ph.D. Student: Brunettová Monika Title of Thesis: Determination of flow properties of mixtures for preparation of tablets containing theophylline The aim of this diploma thesis was to characterize the flow properties and moisture content of mixtures for preparation of tablets containing theophylline. Parameters were monitored depending mainly on the content of the fillers, that were dicalcium phosphate, microcrystalline cellulose and lactose. Twenty-five prepared mixtures with different ratios of these fillers were evaluated. Flowability was evaluated by three methods stated in Czech Pharmacopoeia 2009 - compressibility index and Hausner ratio, flow through an orifice and angle of repose. Moisture content was evaluated as a weight loss during drying. Mixtures containing dicalcium phosphate and lactose proved more appropriate in terms of flowability, their flow properties are passable. However, according to the moisture content, mixture with microcrystalline cellulose are more preferable