Evaluation of activity of potentional antimycotic substances through the use of microdilution broth method IV

Barbora Pašková Evaluation of the activity of potentional antimycotic substances through the use of microdilution broth method IV Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Study program: Pharmacy Background: The aim of this diploma thesis was to evaluate the antimycotic activity of 34 substances prepared at the Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy in Hradec Králové of the Charles University in Prague. Methods: The substances were tested by the microdilution broth method at eight strains of yeasts and filamentous fungi. The tested substances were divided into five groups according to their chemical structure: benzylamino substituted derivates of pyrazine-2- carboxamide, aliphatic aminoderivates of pyrazine-2,3-dicarbonitrile, cyclic aminoderivates of pyrazine-2,3-dicarbonitrile, aliphatic aminoderivates of pyrazine -2-carboxamide, cyclic aminoderivates of pyrazine-2-carboxamide. Results: The highest antimycotic activity was discovered in group of cyclic aminoderivates of pyrazine-2-carboxamide, especially in tested substances OJ101 and OJ103, which showed antimycotic activity to all of strains of yeast and filamentous fungi. On the other hand, substances of group of benzylamino substituted derivates of..