Influencing the early phase of ischemic injury of rat myocardium selected flavonoids

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Bc. Petr Hruška Supervisor: Doc. RNDr. Vladimír Semecký, CSc. Title of thesis: Influencing the early phase of ischemic injury of rat myocardium selected flavonoids Flavonoids are integral constituent of plants, to which are attributed many health beneficial biological activities. In this work we have studied possible cardioprotective effects of their two representatives, quercetin and rutin. The aim of this experiment was to record the effect of quercetin and rutin on influence of possible pathological changes of building components of myocardium. The substances were given to the rats for 7 days p.o. through intragastric tube. The model heart injury of a laboratory rat (adult male Wistar) was induced by one-time administration of isoprenaline (ISO) in both cases of studied substances. The changes caused by ISO have been observed for 24 hours. ISO hasn't been applied to the control groups in either of the experiments. The control group in the experiment with rutin was given sodium bicarbonate instead of rutin. In the groups that weren't pretreated with either quercetin or rutin, there was found similar histological picture after ISO administration. Compared to the control..