A study of the compressibility of direcly compressible tableting materials with tramadol hydrochloride.

This thesis evaluates and compares compressibility of directly compressible tableting materials for the preparation of hydrophilic gel matrix tablets containing tramadol hydrochloride. Prosolv® SMCC 90 and Disintequik™ MCC 25 were used as the dry binders. Hypromelloses Methocel™ Premium K4M and Methocel™ Premium K100M were used in concentrations of 30 % and 50 %. Magnesium stearate was used as the lubricant in concentration of 1%. The compressibility was evaluated by means of the energy profile of the compression process and determination of tensile strength of the tablets. The tableting materials with Prosolv® SMCC 90 exhibited the higher values of the total energy of compression than those with Disintequik™ MCC 25 at the same compression forces, tramadol decreased these values slightly. The tableting materials with Disintequik™ MCC 25 exhibited higher values of the total energy of compression in 50% concentration of both Methocels™ . In the case of Prosolv® SMCC 90 the values of plasticity were higher than at tableting materials with Disintequik™ MCC 25, particularly in 30% concentration of both types of Methocel™ . Tramadol decreased the plasticity slightly. The tableting materials with Prosolv® SMCC 90 provided stronger tablets. Tramadol decreased the strength of tablets and the strength values..