The family of 14-3-3 proteins is one of great regulatory significance, which can be found in all the eucaryotic organisms and consists of seven isoforms in human cells. The function of 14-3-3 proteins rests in the interaction with their ligands, of which several hundreds has been identified. The key role of these partners comes to pass in many cellular processes such as signalization, regulation of a cell cycle and division, apoptosis and others. This thesis deals with the interaction of 14-3-3 protein with fosfatidylinositol 4-kinase IIIβ on a molecular level using the method of X-ray crystallography. Phosphatidylinositol 4-kinase IIIβ (PtdIns4KIIIβ) situated on a cytosol side of mostly Golgi aparatus membranes catalyses the connection of ...
+ssRNA viruses after entering the cell develop platforms for RNA replication called replication orga...
AbstractPhosphatidylinositol (PI) 3-kinase is known as one of the key molecules involved in the vari...
Protein-protein interactions (PPIs) play a crucial role in almost all biological processes. Many pro...
Through binding interactions with more than 300 binding partners, 14-3-3 proteins regulate large amo...
Phosphatidylinositol 4-kinases (PI4K) are enzymes that form phosphatidylinositol-4- phosphate, which...
The 14-3-3 family are homo- and heterodimeric proteins whose biological role has been unclear for so...
Protein-protein interactions (PPIs) play a crucial role in almost all biological processes. Many pro...
Through binding interactions with more than 300 binding partners, 14-3-3 proteins regulate large amo...
The aim of this diploma thesis is a biophysical characterization of the protein complex that consist...
The 14-3-3 proteins are small regulatory biomolecules that are important for many important metaboli...
The 14-3-3 family are homo- and heterodimeric proteins whose biological role has been unclear for so...
Phosphatidylinositol 4-kinases (PI4K/PI4-kinases) catalyse the production of phosphatidylinositol 4-...
Phosphoinositide (PI) 3-kinases have been characterized as enzymes involved in receptor signal trans...
The biosynthesis of phosphosphoinositides underlies a wide range of important biological processes i...
The aim of this project was to identify proteins capable of specifically binding PtdIns(3,4,5)P3 in ...
+ssRNA viruses after entering the cell develop platforms for RNA replication called replication orga...
AbstractPhosphatidylinositol (PI) 3-kinase is known as one of the key molecules involved in the vari...
Protein-protein interactions (PPIs) play a crucial role in almost all biological processes. Many pro...
Through binding interactions with more than 300 binding partners, 14-3-3 proteins regulate large amo...
Phosphatidylinositol 4-kinases (PI4K) are enzymes that form phosphatidylinositol-4- phosphate, which...
The 14-3-3 family are homo- and heterodimeric proteins whose biological role has been unclear for so...
Protein-protein interactions (PPIs) play a crucial role in almost all biological processes. Many pro...
Through binding interactions with more than 300 binding partners, 14-3-3 proteins regulate large amo...
The aim of this diploma thesis is a biophysical characterization of the protein complex that consist...
The 14-3-3 proteins are small regulatory biomolecules that are important for many important metaboli...
The 14-3-3 family are homo- and heterodimeric proteins whose biological role has been unclear for so...
Phosphatidylinositol 4-kinases (PI4K/PI4-kinases) catalyse the production of phosphatidylinositol 4-...
Phosphoinositide (PI) 3-kinases have been characterized as enzymes involved in receptor signal trans...
The biosynthesis of phosphosphoinositides underlies a wide range of important biological processes i...
The aim of this project was to identify proteins capable of specifically binding PtdIns(3,4,5)P3 in ...
+ssRNA viruses after entering the cell develop platforms for RNA replication called replication orga...
AbstractPhosphatidylinositol (PI) 3-kinase is known as one of the key molecules involved in the vari...
Protein-protein interactions (PPIs) play a crucial role in almost all biological processes. Many pro...