Biomechanical Properties of Bones in the Experiment and the Effect of Homocysteine in Bone Health

1 ABSTRACT Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biophysics and Physical Chemistry Candidate: PharmDr. Petra Řeháčková Supervisor: Prof. RNDr. Ing. Stanislav Ďoubal, CSc. Consultants: Doc. MUDr. Štěpán Kutílek, CSc.; Doc. MUDr. Sylva Skálová, Ph.D. Title of Doctoral Thesis: Biomechanical properties of bones in the experiment and the effect of homocysteine on bone health The Doctoral Thesis comprises two basic parts - the Experimental and Clinical. The former one addresses viscoelastic properties of biological materials, in particular bones under dynamic strain. The latter one focuses on the effect of elevated homocysteine levels on bone health. The Introduction includes detailed anatomical description and physiology of human bone, its development, metabolism, and finally some metabolic disorders, the impact of nourishment on its quality and the impact of homocysteine on bone health. Furthermore, the Introduction contains description of Rheological models (described by Hooke's and Newton's elements). As porcine bones resemble human bones in their structure and biomechanical properties, they were used in the Experimental part with the main objective to verify, investigate and measure their characteristics. Two series of measurement with moderate changes in..