Histopathological diagnosis of celiac disease

Celiac disease is associated with a permanent intolerance to gluten, which is included in some cereals. Symptoms of the disease are often subtle and atypical form of the course. The introduction of sensitive methodologies in the form of evidence of serum markers were revealed new positive cases. For example, increasing the intensity of population screening for celiac disease in children and adults, the disease is still under diagnosed in the Czech Republic. This thesis deals with the histopathologic diagnosis. These laboratory and pathological correlation 329 patients. Our aim was to highlight the risk group of persons and the number of types of representation celiac disease according to Marsh classification. This disease can manifest their symptoms from the very beginning to the very relapse. All persons who have undergone gastroduodenoskopické examination and they were sampled tissues lining the descending duodenum. Microscopically for the discovery of mucosal damage typical for celiac disease, which is expressed by Marsha histological classification. Finally, in terms of documenting the histopathological examination findings consistent with celiac disease. Based on our experience, there are several doproučení. First, the targeted screening to determine autoantibodies to tissue transglutaminase...