Effect of ibuprofen on the parameters of compression equation

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Tisoňová Zuzana Consultant: Doc. RNDr. Milan Řehula, CSc. Compacting process is mathematically expressed by compression equations. It is characterized by various parameters of equations. The equation expresses the dependence of the volume, density and height on compacting pressure. In this paperwork, the parameters of compacting equation are evaluated and the pre-loading phase, the phase of elastic deformation and the phase of plastic deformation are studied. This thesis deals with impact of ibuprofen on the parameters of compaction equation. Five mixtures which included microcrystalline celulose and ibuprofen in different ratio 100:0, 75:25, 50:50, 25:75 and 0:100 were studied. Results were based on the three-exponential equation. They were evaluated thanks to box plots. From the results obtained, it is obvious that with decreasing amount of microcrystalline cellulose, the parameter a1 has increased and the parameter E1 also slightly has increased. The composition of the used material didn't have any huge influence on parameters 1/t1 and pH1. During the phase of elastic deformation, the parameters a2 and E2 with decreasing amount of ibuprofen have decreased. On the other hand, the..