Effect of pharmaceuticals present in recipients of STP in fish.

Volume of consumed antibiotics in developed countries have increased eminently in past few decades. These substances are excreted from human body in various abundance and end up in the sewage. Sewage water flow to sewage treatment plants to be partly cleaned and finaly discharged to surface waters. Pharmaceutical residuals leaking to water environment of recipients affect local biota. Impact of pharmaceutical residuals present in biological pond Čežárka was assessed in this study. Čežárka biological pond (2,6 ha) is a recipient of discharged waters of sewage treatment plant in Vodnany, the town with 7 000 inhabitants. Biological ponds are good solution for final treatment of wastewater discharged from sewage treatment plant efluents. The nutrients from wastewater may enter the food chain of pond ecosystem. In total 62 pharmaceuticals were identified in water of sewage pond. Fish exposed in the pond for 30, 90, 180, 320 and 360 days were compared with fish of control group. Growth, condition of fish and biomarkers including level of vitellogenin in blood plasma, lipid peroxidation rate, antioxidative activity of catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase and superoxide dismutase were compared. The study proved the environmental impact of STP dischanrge containing pharmaceutical residuals in fish. Significant adaptation of fish to environment of biological pond was observed after 90 days of exposure